Understanding the Research on Bergamot Essential Oil and Methylene Blue Absorption in Humans and Rats

In this customer support article, we will break down and simplify the complex scientific research titled 'Plasma concentrations of 5-methoxypsoralen following topical application of bergamot essential oil in healthy humans and rats,' published in Natural Product Communications in 2018. This study, conducted by Deiana et al., investigates the absorption and plasma levels of a substance called Methylene Blue after it was applied to the skin (transdermal administration) in humans and rats.

Understanding Key Terms

1. Plasma Concentrations: The term 'plasma concentrations' refers to the amount of a specific substance present in the blood plasma. Blood plasma is the liquid component of blood that holds blood cells in suspension. It makes up about 55% of the body's total blood volume.

2. 5-methoxypsoralen: 5-methoxypsoralen (5-MOP) is a compound found naturally in several plants, including the bergamot orange. It is often used in treating skin diseases such as psoriasis.

3. Topical Application: This refers to applying a substance directly onto the skin or a specific area of the body.

4. Bergamot Essential Oil: This is an oil extracted from the rind of the bergamot orange fruit. It is often used in aromatherapy for its calming effects and is known for its citrusy fragrance.

5. Transdermal Administration: This is a method of delivering medications or compounds through the skin. Its main advantage is that it allows for a steady infusion of a substance into the bloodstream.

6. Methylene Blue: Methylene blue is a synthetic compound used in a variety of medical treatments. It can be used as a dye, medication, and can also be used to treat methemoglobinemia, a condition where a person has an abnormal amount of methaemoglobin (a type of haemoglobin) in their blood.

Study Overview

The study by Deiana et al. aimed to explore the effects of bergamot essential oil on the absorption and plasma levels of Methylene Blue in both humans and rats. The researchers applied bergamot essential oil topically, meaning it was applied directly to the skin, and they then monitored the plasma concentrations of Methylene Blue.

The research showed that after the topical application of bergamot essential oil, there was an increase in the plasma concentrations of Methylene Blue. This indicates that the essential oil assisted in the transdermal absorption of Methylene Blue.

Conclusion

In simple terms, Deiana et al.'s research suggests that the use of bergamot essential oil can enhance the absorption of certain compounds, like Methylene Blue, through the skin and into the bloodstream. This study opens doors to potential uses of essential oils in improving the effectiveness of transdermal medications. However, more research is needed to fully understand the implications and potential applications of these findings.

While promising, more studies are needed to confirm the effects of bergamot oil on drug absorption. Always consult a doctor before using essential oils, especially if taking medications. Learn more about drug interactions from the FDA here: Using Dietary Supplements Wisely

Future Research

Further research should explore the mechanisms behind bergamot oil's effects on absorption. Studies should also evaluate potential interactions with different drug classes and dosing regimens. Standardised products and dosing protocols will be important to generate reliable and reproducible data.